936Tolerability, Adherence and Completion of New Occupational HIV Post-Exposure Prophylaxis Regimens (Tenofovir + Emtricitabine and Raltegravir)
نویسندگان
چکیده
Post-Exposure Prophylaxis Regimens (Tenofovir + Emtricitabine and Raltegravir) Izona Bock, MD; Uriel Felsen, MD; Michela Catalano, MD; Susan Hacker, MD; Barry Zingman, MD; Infectious Diseases, Montefiore Medical Center, Bronx, NY; Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY; Occupational Health, Albert Einstein College of Medicine, Bronx, NY; Occupational Health, Montefiore Medical Center, Bronx, NY
منابع مشابه
Optimal HIV Postexposure Prophylaxis Regimen Completion With Single Tablet Daily Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine Compared With More Frequent Dosing Regimens.
STRUCTURE The study evaluated elvitegravir/cobicistat/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) ("Quad pill") for postexposure prophylaxis (PEP). BACKGROUND HIV-exposed individuals may benefit from PEP, but completion rates have been suboptimal because of regimen complexity and side effects. Newer antiretroviral combinations coformulated as single daily pills may optimize PEP ad...
متن کامل1529Raltegravir Plus Tenofovir DF and Emtricitabine for Non-occupational Postexposure Prophylaxis (nPEP): African-Americans are at Higher Risk of Non-Completion of nPEP
Background. Current guidelines recommended the use of antiretrovirals after non-occupational exposure to HIV. However recommended regimens are based on 2005 drug pipeline. Since then significant advances in antiretroviral therapy have been achieved. This study aimed to assess the safety and tolerability of tenofovir DF/ emtricitabine/raltegravir for non-occupational post exposure prophylaxis af...
متن کاملRaltegravir, tenofovir DF, and emtricitabine for postexposure prophylaxis to prevent the sexual transmission of HIV: safety, tolerability, and adherence.
Antiretroviral drugs have been recommended for postexposure prophylaxis (PEP) after high-risk sexual exposures for more than a decade. Three drug regimens could offer the highest levels of protection, particularly if the infectious source is taking medication, but drug intolerance has often led to suboptimal adherence. The current study evaluated a novel 3-drug PEP regimen, consisting of ralteg...
متن کاملSafety, Adherence and Acceptability of Intermittent Tenofovir/Emtricitabine as HIV Pre-Exposure Prophylaxis (PrEP) among HIV-Uninfected Ugandan Volunteers Living in HIV-Serodiscordant Relationships: A Randomized, Clinical Trial
BACKGROUND Efficacy of oral pre-exposure prophylaxis (PrEP) in prevention of HIV acquisition has been evaluated using a daily regimen. However, adherence to long term daily medication is rarely perfect. Intermittent regimen may be a feasible alternative. Preclinical studies have demonstrated effectiveness of intermittent PrEP in SHIV prevention among animals. However, little is known about inte...
متن کاملSingle-Tablet Emtricitabine-Rilpivirine-Tenofovir as HIV Postexposure Prophylaxis in Men Who Have Sex With Men.
BACKGROUND Completion rates for human immunodeficiency virus (HIV) postexposure prophylaxis (PEP) are low. We investigated the adherence and safety of coformulated emtricitabine (FTC), rilpivirine (RPV), and tenofovir disoproxil fumarate (TDF) as a 3-drug, single-tablet regimen for PEP in men who have sex with men (MSM). METHODS In an open-label, single-arm study at 2 public sexual health cli...
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